Health & Care Information
Learn all about Osteosclerosis definition, symptoms, causes and treatment. Osteosclerosis (osti-oh-skleer-oh-sis) is a disorder that is characterized by abnormal hardening of bone and an elevation in bone density. It makes bones heavier, but also more fragile. In those animal groups osteosclerosis often occurs together with bone thickening it may predominantly affect the medullary portion and/or cortex of bone. Plain radiographs are a valuable tool for detecting and classifying osteosclerotic disorders. It can manifest in localized or generalized osteosclerosis.
Osteosclerosis is a type of osteopetrosis that involves abnormal hardening of bone that involves increased skeletal density with little disturbance of modeling; in some types, bony encroachment on the marrow cavity causes cytopenias. Osteosclerosis can be classified in accordance with the causative factor into acquired and hereditary. In some rare cases, the Osteosclerosis can cause the bone of the ear to have a fracture as well.
The problem of Osteosclerosis can be identified with the help of symptoms. These symptoms can make the diagnosis easier for the doctor. The symptoms that are associated with this disease are fractures, optic atrophy, protruding forehead, bone pain, facial palsy, osteomyelitis and anemia.
As far as the causes are concerned, there are multiple factors that can lead to the issue of Osteosclerosis. The Localized Osteosclerosis is a problem that can be related to family issues like the heredity. Some of the primary causes of Osteosclerosis some primary diseases such as prostate cancer, myelofibrosis, Erdheim-Chester disease, sclerosteosis and hemangioma. This type of osteopetrosis is autosomal recessive. The genetic defect involves mutations of the gene encoding carbonic anhydrase II. It causes weakness, stunted stature, and failure to thrive.
The treatment of Osteosclerosis is long enough; you should do the prevention and timely treatment of complications. It may be skeletal deformities, changes in blood composition. Since osteosclesoris is primarily considered to be not a disease, there is no treatment required for it. Osteosclerosis gets worse without treatment. Surgery may restore at least some of your hearing. Pain and dizziness from the surgery usually go away within a few weeks.
What is Osteosclerosis
Osteosclerosis is a very rare disorder that is identified by primarily by a rare elevate in the bone density. This means as the old bone is not resorbed and is not replaced with a new bone. This is why it is also identified as the marble bone disease. The Osteosclerosis is also called as the marble bone disease.
Osteosclerosis Definition
Osteosclerosis is an abnormal increase in the density of bone tissue. The condition occurs in a variety of disease states and is commonly associated with ischemia, chronic infection, and tumor formation. It also may be caused by faulty bone resorption as a result of some abnormality involving osteoclasts. An imbalance in the metabolism of calcium ions results in a high concentration of bone minerals in cortical bones, which leads to a tendency towards excessive calcification of the bones.
Osteosclerosis Symptoms
In osteosclerosis, bone density is abnormally high. Associated symptoms include fractures, anemia, and bone pain. The hands and feet may be poorly developed. The fingers and toes may be abnormally curved. The problem of Osteosclerosis can be identified with the help of symptoms. These symptoms can make the diagnosis easier for the doctor. As Osteosclerosis is a problem that is related to bones, the patient suffering from the Osteosclerosis can have hearing issues as well. Likewise, at the initial stages, the patient might be slow in hearing and later with the passage of time, it can worse. There is a problem called tinnitus, in this problem, there is consistent ringing sound in the ears. It is one of the indications that can refer to the issue. A patient having Osteosclerosis can feel little dizzy all the time
Osteosclerosis Causes
Main causes of Osteosclerosis are;
- Congenital disorders
- Osteopetrosis
- Carbonic anhydrase II deficiency
- Pycnodysostosis
- Progressive diaphyseal dysplasia*
- Hyperphosphatasia
- Chemical poisoning
- Fluorosis
- Hypervitaminosis A. D
- Biphosphonate intoxication
- Endocrine disorders
- Primary hyperparathyroidism
- Secondary hyperparathyroidism
Osteosclerosis Treatment
- Osteosclerosis treatment includes the use of Interferon gamma-1b. Since osteosclesoris is primarily considered to be not a disease, there is no healthcare treatment required for it. However, regular x-rays are recommended to check the progress of the disorder, if there is any.
- Vitamin and mineral supplementation: Individuals with osteosclerosis and ectodermal dysplasia may suffer from malabsorption, the inability to absorb nutrients in the digestive tract. Depending on the individual needs of a patient with malabsorption, vitamin and mineral supplements may be recommended. These may include single-nutrient supplements, such as vitamin C, or combination supplements, such as a multivitamin with minerals.
- Surgery: Atrial septal defect, a heart condition seen in osteosclerosis and ectodermal dysplasia, is essentially a hole in the muscle wall that separates the two atria of the heart. If the hole is large, oxygen-rich blood may leak from the left atrium back into the right, causing the heart to work inefficiently. If an atrial septal defect is detected and assessed, it may be corrected by surgery. Surgical closure of an atrial septal defect involves opening up at least one atrium and closing the defect with a patch.
- Bone marrow transplant: A bone marrow transplant is an option for people with severely decreased levels of neutrophils. Bone marrow is a spongy tissue found inside bones. The bone marrow in the breastbone, skull, hips, ribs, and spine contains stem cells that produce the body’s blood cells. These blood cells include leukocytes (white blood cells), which fight infection; erythrocytes (red blood cells), which carry oxygen; and platelets, which enable the blood to clot. A bone marrow transplant, also called a stem-cell transplant, is a procedure in which diseased or damaged bone marrow cells are replaced with healthy ones.
