Middle Lobe Syndrome Symptoms, Causes, Diagnosis, Treatment

Middle lobe syndrome or an MLS is a rare disorder of the lungs; involving the right middle lobe or/and lingula in particular. The most common definition of this lobe syndrome is the chronic or recurrent collapse of the middle lobe of the right lung. In 1948, Graham was the person to report 12 patients with nontuberculous pneumonitis and atelectasis. Later, Ervin and Effler referred to this syndrome as Middle lobe syndrome.

Though this syndrome is related to the lungs; however sometimes it may hurt the lingula too. The Middle lobe syndrome is more common in females than males. There are pathophysiologically two categories of the right middle lobe syndrome, that is, obstructive and non-obstructive. The obstructive middle lobe syndrome is caused; by extrinsic compression or endobronchial lesions.

Middle Lobe Syndrome Symptoms

There are several signs and symptoms associated with middle lobe syndrome. However, some of the most common symptoms exhibited by the affected individuals include a recurrent or chronic cough. It is essential to mention that this symptom is visible in approximately 30 to 50% of the patients.
Other symptoms of it include shortness of breath or dyspnea, audible wheezing, and pain in the chest. It also mentions fever and chills in relevance to obstructive pneumonia. The abovementioned symptoms are sometimes recurrent and sporadic. The history for repeated treatments of this syndrome may also include asthma or recurrent pneumonia.

The ratio of the existence; of middle lobe syndrome of females to males usually ranges between 1.5 to 3. However, it is essential to mention that this syndrome is unrecognized in clinical practice. For this reason, sometimes, identifying the constellations of its symptoms and signs; may be a challenge from a diagnostic point of view.

Middle Lobe Syndrome Symptoms, Causes, Diagnosis, Treatment

Middle Lobe Syndrome Causes

Several causes are known to cause the collapse of the middle right lobe of the lungs. The etiology of the above-mentioned two categories of this syndrome is not the same. The obstructive middle lobe syndrome arises from extrinsic compression of the right middle lobe bronchus. This compression results due to the existence of tumors or peribronchial lymphadenopathy. The extrinsic compressions involve primary lung cancers, hamartomas, a plethora of tumors, and sometimes distant metastasis. However, another common etiology of the syndrome includes mucus plugs, aspiration, sarcoidosis, and broncholiths.

On the contrary, there is no recognizable obstruction behind the non-obstructive middle lobe syndrome. And for this reason, the basis of the physiology of recurrent atelectasis is not clearly understood. However, nonobstructive middle lobe syndrome results from transient hypoventilation in conditions such as cystic fibrosis. The middle lobe syndrome may also arise due to bronchopulmonary cysts, a broad range of infections, and pulmonary infarcts.

Middle Lobe Syndrome Diagnosis

From a medical point of view, a few tests and imaging models are available to accompany the diagnosis of middle lobe syndrome. Though there is a wide range of tests and imaging modalities available, however; not one of those is supposed to be a standard for diagnostic purposes.

The initial evaluation or diagnosis of the syndrome may include a lateral view chest X-ray. However, sometimes there may also be an exhibition of plain films in patients with recurrent pneumonia, which is normal.

An evaluation based upon radiography may also imply. However, it will never lead to the underlying cause of the syndrome. Total blood count, bronchoscopy or/and CT(computed tomography) chest are some medical methods used to help further in elucidating the actual disease process behind. Another diagnosis of it is the right heart border obscured in both AP or PA projections.

Middle Lobe Syndrome Treatment

The treatment or management of this syndrome is of vital significance. Whether the case is related to the obstructive category or a non-obstructive one, the central focus is identifying the underlying disease process. The agents are focused on the optimization of pulmonary function. These agents include antibiotics, chest physiotherapy, mucolytics, and bronchodilators. The abovementioned list of agents benefits nearly all the patients irrespective of the type of syndrome they show.

Rigid or fiberoptic bronchoscopy also allows in eliminating the intrabronchial tumors or foreign bodies. The clinicians also reported using insufflation for a lobar collapse along with fiberoptic bronchoscopy. The surgical intervention as well plays a valuable role if the above-mentioned methods fail.

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