Opdivo/Nivolumab Lung Cancer Treatment Side effects, Cost

Opdivo/Nivolumab medicine is the new approved by FDA. Opdivo is better than all other chemotherapeutic agents. Opdivo/Nivolumab cost, side effects, indications and results are discussed in this article.

Lung is also termed as pulmonary carcinoma or lung cells carcinoma.It is basically malignant type of tumor (uncontrolled growth of cells). has various stages and treatment of lung cancer is specifically designed according type and stage of lung cancer. Early stages have high survival rate while late stages have low survival rate depending upon the other factors like age, gender and health condition of the patient.

There are basically two types of lung cancer i.e small cell lung cancer and non-small cell lung cancer.

Small Cell Lung Cancer
As name indicates small cell lung cancer contains small cancerous cell with dense neurosecretory granules(Neuroendocrine hormones vesicles). The most coomon site or area of such type of lung cancer is primary and sceondary bronchi. Major cause of small cell lung cancer is smoking and it spreads very quickly into the lungs.

Non-Small Cell Lung Cancer
Small cell lung cancer is further divided into three subtypes adenocarcinoma, squamous cell carcinoma and large cell carcinoma.The most common type of carcinoma is adenocarcinoma which about 40% of all types of lung cancer disease. Second most prevalent and deadly type of lung cancer is squamous cell carcinoma which is about 30% of all types of lung cancer disease. Large cell carcinoma is a rare type type of lung cancer. It is so named because cancer cells are too large due to excess of cytoplasm and conspicuous nucleoli.

Opdivo/Nivolumab Lung Cancer Treatment Side effects, Cost

Let’s look at Opdivo/Nivolumab lung cancer treatment side effects, cost and indications:

Opdivo/Nivolumab Lung Cancer Treatment Side effects, Cost

Nivolumab is basically anti PD 1 monoclonal antibody approved by FDA on March 4, 2015 for the treatment of advance metastatic squamous non-small cell lung cancer (NSCLC). FDA gives approval of nivolumab for lung cancer treatment due to its high survival rate as compared to other chemotherapeutic agents. It is marketed by Bristol-Myers Squibb under the trade name of Opdivo. Main mechanism of action of nivolumab is direct inhibition of tumor growth via inhibitory ligand blocking antibody against the programmed death receptor. Nivolumab is kind of targeted anti cancer therapy as compared to traditional chemothrapies.

Opdivo/Nivolumab for Lung Cancer Treatment

FDA approved Opdivo (nivolumab) first for the treatment of unresectable melanoma and metastatic melanoma who are not responding to other conventional chemotherapeutic agents.

On On March 4, 2015, the US. Food and Drug Administration granted approval for the treatment of metastatic squamous non-small cell lung cancer (NSCLC). The decision was made due to good results and high survival rates in lung cancer treatment. Opdivo/nivolumab was found better than all other chemotherapeutic agents like docetaxel.

Opdivo/Nivolumab Cost for Lung Cancer Treatment Therapy

Opdivo comes under the category of specialty medications due to which it is expensive one. Opdivo cost in USA for 10ml vial (Nivolumab 100mg/10ml) is about $2454 USD.

Opdivo price in United States for a 4ml vial (Nivolumab 40mg/4ml) is around $991. This is approximate cost of drug, collected through a market survey. Total cost of therapy varies from patient to patient. Opdivo cost for cancer treatment depends upon parameters like cancer stage, type of cancer and age of patient.

Generally, it is estimated that Opdivo cancer treatment total therapy costs from $150000 to $200000.

Opdivo/Nivolumab Side Effects

According to FDA clinical trials most common type of Opdivo/nivolumab side effects of are:

  1. Fatique
  2. Dyspnea
  3. Musculoskeletal pain

Some other serious type of nivolumab side effects includes:

  1. Pneumonitis
  2. Colitis
  3. Hepatitis
  4. Nephritis/Renal dysfunction
  5. Hypothyroidism
  6. Hyperthyroidism

About Dr. Arslan Malik

Dr. Arslan Malik
Arslan Malik is noted health blogger, public health activist, aspiring dreamer and avid reader. With doctor in pharmacy, he has worked closely with various health organizations, multinational pharmaceuticals and community health programs. Beside his professional practice, he has an avid interest in writing and teaching Physiology and Medicines. He covers variety of topics from Nutrition and Natural Care to Diseases, Treatments, Drug Interactions, Preventive Care and Clinical Research.

One comment

  1. peter

    Do you know what is the cost of
    having opdivo treatment in China ?

Leave a Reply

Your email address will not be published. Required fields are marked *