Learn all about MacGregor’s Syndrome. MacGregor’s Syndrome is a terminal disease, which may be a result of drug use. Drug addiction is a chronically relapsing disorder that has been characterized by; compulsion to seek and take the drug, loss of control in limiting intake, and emergence of a negative emotional state (e.g. dysphoria, anxiety, irritability) reflecting a motivational withdrawal syndrome when access to the drug is prevented. Drug addiction has been conceptualized as a disorder that involves elements of both impulsivity and compulsivity that yield a composite addiction cycle composed of three stages: ‘binge/intoxication’, ‘withdrawal/negative affect’, and ‘preoccupation/anticipation’ (craving).
William Tockman, a former bank robber, suffered from MacGregor’s Syndrome. However, rather than using the money he stole; he gave it to his sister. His plans were eventually stopped by Felicity Smoak. Francine West was also diagnosed with the disease, being given until the end of 2015, at most, to live. Due to this, she sought to reconnect with her estranged daughter Iris West
The fictional disease first appeared in the 1992 cartoon Batman: The Animated Series as a disease contracted by the super villain Mr. Freeze’s wife that forced Freeze to put her in suspended animation. The disease was not however named until the 1997 movie Batman & Robin. Mr. Freeze was working on a cure for his wife Nora before the accident. Later in the film, Alfred Pennyworth is revealed to also be suffering from the early stages of the disease.
MacGregor’s seems to be a Glamorous Hollywood Wasting Illness straight out of the 1940s, which makes its abrupt outbreak in the mid-1990s film Batman & Robin all the more inexplicable. Probably Joel Shumacher tampered in God’s domain, or something. Mr. Freeze’s wife, Nora Freeze, was in a late stage of the disease when Freeze froze her, hopefully forgoing once of his ice-based puns. He managed to develop an antidote that will reverse the illness, but only up to stage-1 which, it just so happens, Alfred Pennyworth has.
Therapeutic aspiration may be sufficient; larger effusions may require insertion of an intercostal drain (either pigtail or surgical). When managing these chest tubes, it is important to make sure the chest tubes do not become occluded or clogged. A clogged chest tube in the setting of continued production of fluid will result in residual fluid left behind when the chest tube is removed. This fluid can lead to complications such as hypoxia due to lung collapse from the fluid or fibrothorax if scarring occurs.
What is Macgregor’s syndrome
MacGregor’s Syndrome leads to the fluid buildup in the lungs. The mitochondria oxidize the calories in our diet with the oxygen that we breathe to generate. When a new mutation arises in the mtDNA, it creates an intracellular dysfunction result in a wide range of multisystem degenerative diseases. However, the lung is a complex organ, and there are many causes of this excess fluid accumulation. Regardless of the cause, fluid makes it difficult for the lungs to function (to exchange oxygen and carbon dioxide with cells in the bloodstream).
Macgregor’s syndrome Definition
MacGregor’s syndrome is a genetic defect that creates fluid buildup in the lungs, which leads to oxygen deprivation and multi-system organ failure. It was known to affect exdrug addicts. Velocardiofacial syndrome and Cayler cardiofacial syndrome are also included in this group of disorder.
Macgregor’s syndrome Symptoms
The symptoms range from shortness of breath to loss of life and victims range from younger attractive women to elderly British men. Some of the symptoms are;
- Celiac, accepted
- Blood-sugar problems (diabetes type 1 is accepted)
- Glomerulonephritis partly autoimmune (only recently confirmed)
- Meniere’s disease, suspected
- Psoriasis, accepted
- Psoriatic arthritis, accepted/Ankylosing spondylitis, suspected
- Restless Legs Syndrome, suspected.
Macgregor’s syndrome Causes
Macgregor’s syndrome less often may be associated with:
- Head or neck injury
- Brain problems such as stroke or tumor
- Certain medications that cause ear damage
- Migraine headaches
Macgregor’s syndrome Treatment
Macgregor’s syndrome treatment depends on the condition of the disease. The safety and tolerability of modafinil (400 mg/day) and mirtazapine (60 mg/day) in inpatient methamphetamine withdrawal treatment were compared to a historical comparison group receiving treatment as usual (pericyazine, 2.5-10 mg/day). Modafinil and mirtazapine were well tolerated, producing minimal positive subjective effects and no discontinuation effects in this open-label study. Side effects were mild and transient. Aches and pains were most commonly reported by participants receiving mirtazapine, whereas headache was reported by modafinil-treated participants.
Modafinil-treated participants had a milder withdrawal syndrome as measured by the Amphetamine Cessation Symptom Assessment and less sleep disturbance in comparison to mirtazapine. Pericyazine was associated with a more severe withdrawal syndrome in comparison to mirtazapine and modafinil. Both modafinil and mirtazapine were safe and well tolerated in methamphetamine withdrawal treatment. However, these early findings of efficacy in symptom amelioration should be replicated in an adequately powered, randomized, placebo-controlled double-blind design.